主要研究内容有氮杂环卡宾金属络合物的合成及应用、过渡金属催化卡宾的官能化、共价有机框架（COFs）的设计合成及其在电化学储能上的应用。目前在Org. Lett.、Energy Storage Materials、Nano Energy 、Chem. Commun.、Adv. Synth. Catal.、Tetrahedron、Mater. Today Chem.、J. Org. Chem.、Nat. Commun.、Angew. Chem. Int. Ed、Cell Rep. Phys. Sci.等权威期刊发表SCI论文20余篇。
主持和作为主要参与人参加的科研项目：
安徽工业大学博士引进科研启动经费，10万，在研，主持
“基于α-亚胺基金卡宾中间体的含氮杂环化合物的合成研究”（国家自然科学基金/青年基金No. 21402197），结题，参与
“基于金属卡宾中间体合成α-氟代氨基酸衍生物的研究”（国家自然科学基金/青年基金No. 21502190），结题，参与
“基于钯卡宾的迁移插入反应合成中环内酯和中环内酰胺”（国家自然科学基金/面上项目No. 21871259），在研，参与
代表性论文及成果：
(1) Lei Zhu, Qiwang Shao, Changyou Zhang, Xianjia Cao, Dongming Liu*, Chunyi Zhi*,Donghong Wang* Chemical design of covalent organic frameworks for aqueous zinc batteries Energy Storage Materials 2024, 67, 103297. (IF:20.4, 中科院一区)
(2) Donghong Wang, Chuan Li, Qing Li, Hongfei Li, Javed Rehman, Chunyi Zhi*, Lei Zhu**, Unraveling the high Energy efficiency for Zn||metal hexacyanoferrate batteries in a zinc-potassium hybrid configuration Nano Energy 2023, 104, 107990.(IF:19.069, 中科院一区)
(3) Xiaoru Cao, Qingmei Shi, Yangyang Feng, Xiang Zhang, Enbo Zhou, Lei Zhu**, Yaobing Wang* Pyrazine and crown ethers: functional covalent organic polymers for (solar-assisted) high capacity and rate performance lithium-organic battery. Mater. Today Chem. 2023, 26, 101082. (IF:7.613, 中科院二区)
(4) Lei Zhu, Xiaojian Ren, Yinghua Yu, Pengcheng Ou, Zhi-Xiang Wang, Xueliang Huang* Palladium-Catalyzed Three-Component Coupling Reaction of o Bromobenzaldehyde, N Tosylhydrazone, and Methanol. Org. Lett. 2023, 22, 2087-2092.(IF:6.072, 中科院一区)
(5) Lei Zhu#, Yinghua Yu#, Zhifeng Mao, and Xueliang Huang* Gold-Catalyzed Intermolecular Nitrene Transfer from 2H-azirines to Ynamides: A Direct Approach to Polysubstituted Pyrroles. Org. Lett. 2015, 17, 30-33. (#共同一作，IF = 6.072, 中科院一区，被引频次：161，Highlighted by Organic Chemistry Portal )
(6) Xiaojian Ren#, Lei Zhu#, Yinghua Yu, Zhi-Xiang Wang,* Xueliang Huang* Understanding the Chemoselectivity in Palladium-Catalyzed Three-Component Reaction of o-Bromobenzaldehyde, N-Tosylhydrazone, and Methanol. Org. Lett. 2023, 22, 3251-3257. (#共同一作，IF:6.072, 中科院一区)
(7) Xing Cheng#, Lei Zhu#, Meijun Lin, Jianxin Chen*, Xueliang Huang* Rapid access to cyclopentadiene derivatives through gold-catalyzed cycloisomerization of ynamides with cyclopropenes by preferential activation of alkenes over alkynes. Chem. Commun. 2017, 53, 3745-3748. (#共同一作，IF:6.065, 中科院二区,自然指数期刊)
(8) Lei Zhu, Ting-Ting Gao, Li-Xiong Shao* Well-defined NHC-Pd(II)-Im (NHC = N-heterocyclic carbene; Im=1-methylimidazole) complexes catalyzed amination of arylchlorides. Tetrahedron, 2011, 67, 5150-5155. (IF = 2.457， 被引频次：82)
(9) Lei Zhu, Yue-Mei Ye, Li-Xiong Shao* Well-defined NHC-Pd(II)-Im (NHC = N-heterocyclic carbene; Im=1-methylimidazole) complexes catalyzed C-N coupling of primary amines with aryl chlorides. Tetrahedron, 2012, 68, 2414-2420. (IF = 2.457, 被引频次：56)
(10) Yufeng Wu#, Lei Zhu#, Yinghua Yu#, Xuesong Luo, Xueliang Huang* Polysubstituted 2‑Aminopyrrole Synthesis via Gold-Catalyzed Intermolecular Nitrene Transfer from Vinyl Azide to Ynamide: Reaction Scope and Mechanistic Insights. J. Org. Chem. 2015, 80, 11407−11416. (#共同一作，IF = 4.354, 被引频次：73)
(11) Yinghua Yu#, Lei Zhu#, Yun Liao, Zhifeng Mao, Xueliang Huang* Rhodium(II)-Catalysed Skeletal Rearrangement of Ether Tethered N-Sulfonyl 1,2,3-Triazoles: a Rapid Approach to 2-Aminoindanone and Dihydroisoquinoline Derivatives. Adv. Synth. Catal. 2016, 358, 1059-1064. (#共同一作，IF = 5.981,中科院二区)
(12) Meijun Lin, Lei Zhu, Jiajin Xia, Yinghua Yu, Jianxin Chen*, Zhifeng Mao*, Xueliang Huang* Gold-Catalyzed Oxidative Cyclization of Tryptamine Derived Enynamides: A Stereoselective Approach to Tetracyclic Spiroindolines. Adv. Synth. Catal. 2018, 360, 2280-2284. (IF = 5.981, 中科院二区)
(13) 邵黎雄，陆建梅，朱磊 氮杂环卡宾-金属钯-咪唑络合物催化芳基氯化物在胺化反应中的应用，中国发明专利，CN 102432411 A
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