该基因编码 cGMP 抑制的环核苷酸磷酸二酯酶 (cGI-PDE) 家族的成员。 cGI-PDE 酶水解 cAMP 和 cGMP，并通过调节细胞内环核苷酸信号的幅度和持续时间在许多细胞过程中发挥关键作用。编码的蛋白质介导血小板聚集，并通过调节血管平滑肌收缩和松弛在心血管功能中发挥重要作用。所编码蛋白质的抑制剂可有效治疗充血性心力衰竭。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 9 月]
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE Enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]