该综述考虑了糖皮质激素对胃粘膜的生理和药理作用的数据，并着重于应激产生的糖皮质激素的胃保护作用，以及糖皮质激素的生理性胃保护作用向病理性促胃溃疡作用的转化。重新评估压力产生的糖皮质激素是致溃疡性传统观念的实验研究结果使我们得出了相反的结论，表明这些激素在维持胃粘膜完整性中起着重要作用。外源糖皮质激素可能发挥胃保护作用和促溃疡作用。最初，地塞米松的胃保护作用而不是皮质酮，皮质醇或泼尼松龙的胃保护作用可以转化为致溃疡的作用。转化的最重要因素是其作用的延长而不是剂量的延长。胃肠道损伤可伴有躯体疼痛敏感性的变化，而糖皮质激素可促进这些变化，从而发挥生理和病理作用。
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Physiological and Pharmacological Effects of Glucocorticoids on the Gastrointestinal Tract.
The review considers the data on the physiological and pharmacological effects of glucocorticoids on the gastric mucosa and focuses on the gastroprotective role of stress-produced glucocorticoids as well as on the transformation of physiological gastroprotective effects of glucocorticoids to pathological proulcerogenic consequences. The results of experimental studies on the re-evaluation of the traditional notion that stress-produced glucocorticoids are ulcerogenic led us to the opposite conclusion suggested that these hormones play an important role in the maintenance of the gastric mucosal integrity. Exogenous glucocorticoids may exert both gastroprotective and proulcerogenic effects. Initially, gastroprotective effect of dexamethasone but not corticosterone, cortisol or prednisolone can be transformed into proulcerogenic one. The most significant factor for the transformation is the prolongation of its action rather the dose. Gastrointestinal injury can be accompanied by changes in somatic pain sensitivity and glucocorticoids contribute to these changes playing a physiological and pathological role.