口腔粘膜在防止物理、微生物和化学伤害方面具有重要作用。这种屏障的破坏会触发伤口愈合反应。这种反应中的关键事件，如免疫浸润、再上皮化和基质重塑，由促进细胞迁移、侵袭和增殖的细胞因子协调。细胞因子介导的细胞侵袭和迁移也是癌症传播的重要特征。因此，探索调节口腔伤口愈合每个阶段的细胞因子将提供关于口腔鳞状细胞癌 (SCC) 利用细胞因子促进肿瘤发展和进展的见解。这将有助于确定潜在的治疗靶点，以限制 SCC 复发并提高患者存活率。在这篇评论中，
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Cytokines secreted by inflamed oral mucosa: implications for oral cancer progression
The oral mucosa has an essential role in protecting against physical, microbial, and chemical harm. Compromise of this barrier triggers a wound healing response. Key events in this response such as immune infiltration, re-epithelialization, and stroma remodeling are coordinated by cytokines that promote cellular migration, invasion, and proliferation. Cytokine-mediated cellular invasion and migration are also essential features in cancer dissemination. Therefore, exploration of cytokines that regulate each stage of oral wound healing will provide insights about cytokines that are exploited by oral squamous cell carcinoma (SCC) to promote tumor development and progression. This will aid in identifying potential therapeutic targets to constrain SCC recurrence and increase patient survival. In this review, we discuss cytokines that overlap in oral wounds and SCC, emphasizing how these cytokines promote cancer progression.